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Synthesis of Pyrene‐4,5‐dione on a 15 g Scale
Author(s) -
Walsh Joshua C.,
Williams KerryLynn M.,
Lungerich Dominik,
Bodwell Graham J.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601198
Subject(s) - chemistry , pyrene , yield (engineering) , combinatorial chemistry , scale (ratio) , scalability , product (mathematics) , organic chemistry , database , computer science , materials science , physics , geometry , mathematics , quantum mechanics , metallurgy
A scalable and efficient method for the synthesis of pyrene‐4,5‐dione has been developed. The addition of N ‐methylimidazole (NMI, 5 mol‐%) to a known oxidation reaction was shown to marginally improve the yield and dramatically improve the ease of the workup and thus the amount of product isolable in a day by using regular laboratory equipment.