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Synthesis of Thiazolidine‐2‐thiones through a One‐Pot A 3 ‐Coupling–Carbon Disulfide Incorporation Process
Author(s) -
Nechaev Anton A.,
Peshkov Anatoly A.,
Van Hecke Kristof,
Peshkov Vsevolod A.,
Van der Eycken Erik V.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601103
Subject(s) - chemistry , carbon disulfide , thiazolidine , aldehyde , amine gas treating , alkyne , coupling (piping) , disulfide bond , carbon fibers , combinatorial chemistry , organic chemistry , catalysis , mechanical engineering , biochemistry , materials science , composite number , engineering , composite material
A copper‐catalyzed two‐step one‐pot procedure for the synthesis of thiazolidine‐2‐thiones has been developed. The process involves a three‐component coupling of an alkyne, an aldehyde, and an amine (A 3 ‐coupling) followed by trapping the resulting propargylamine with carbon disulfide and subsequent cyclization.