Premium
Site‐Selective C–H Amidation of Azobenzenes with Dioxazolones under Rhodium Catalysis
Author(s) -
Mishra Neeraj Kumar,
Oh Yongguk,
Jeon Mijin,
Han Sangil,
Sharma Satyasheel,
Han Sang Hoon,
Um Sung Hee,
Kim In Su
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601096
Subject(s) - chemistry , rhodium , catalysis , combinatorial chemistry , organic chemistry
The rhodium(III)‐catalyzed amidation reaction of azobenzenes with dioxazolones is described. This strategy allows the facile and efficient construction of highly substituted ortho ‐amidated azobenzenes by direct C–H cleavage approach. A wide range of substrates, excellent levels of chemoselectivity as well as high functional‐group tolerance were observed. In addition, this protocol was used to generate an array of ortho ‐amidated ketazines. Further synthetic transformation of amidated azobenzenes furnished a facile construction of benzimidazole and benzotriazole derivatives.