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Transition‐Metal‐Catalyzed Transformations of 1‐Alkenylpropargyl Alcohols and Esters: Valuable Cascade Reactions for Increasing Structural Complexity
Author(s) -
Haak Edgar
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601076
Subject(s) - chemistry , cascade , combinatorial chemistry , catalysis , cascade reaction , transition metal , context (archaeology) , structural motif , organic synthesis , drug discovery , functional diversity , nanotechnology , organic chemistry , paleontology , biochemistry , chromatography , biology , ecology , materials science
It is the aim of this microreview to highlight the diversity of structural conversions that are accessible from 1‐alkenylpropargyl alcohols and esters in the context of transition‐metal‐catalyzed cascade transformations. These readily available enynols facilitate diverse transition‐metal‐catalyzed cascade reactions, exploiting their different functional sites. This C 5 motif thus represents a set of common precursors for a broad range of structurally very diverse scaffolds, making its cascade transformations valuable tools in organic synthesis and drug discovery.