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Palladium‐Catalyzed Acylation of Arenes by 1,2,3‐Triazole‐Directed C–H Activation
Author(s) -
Zhao Fen,
Chen Zhen,
Liu Yaowen,
Xie Kai,
Jiang Yubo
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601061
Subject(s) - chemistry , acylation , regioselectivity , aldehyde , palladium , catalysis , ketone , triazole , combinatorial chemistry , organic chemistry , 1,2,3 triazole
A facile and efficient method for the regioselective acylation of 1,4‐disubstituted 1,2,3‐triazoles by using a Pd‐catalyzed C–H bond‐activation strategy with tert ‐butyl hydroperoxide (TBHP) as an oxidant and an aromatic aldehyde as the acyl source has been developed. This synthetic approach was applied to a wide range of substrates to generate various 1,2,3‐triazole derivatives that contain the diaryl ketone scaffold.