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Palladium‐Catalyzed Intramolecular C–H Amination in Water
Author(s) -
Yang Lizheng,
Li Hao,
Zhang Haifei,
Lu Hongjian
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601043
Subject(s) - chemistry , amination , intramolecular force , palladium , catalysis , carbazole , functional group , organic chemistry , combinatorial chemistry , polymer
Palladium(II) catalysis was found to be effective for intramolecular C–H amination in water. With 2‐azidobiphenyls as substrates, the reaction efficiently provided various carbazoles with N 2 as the sole byproduct. The reaction showed high functional‐group tolerance and could be used in the synthesis of several natural carbazole alkaloids. The catalytic process was promoted by water, and the reaction was inefficient in the organic solvents that were investigated.