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Efficient Synthesis of Functionalized β‐Keto Esters and β‐Diketones through Regioselective Hydration of Alkynyl Esters and Alkynyl Ketones by Use of a Cationic NHC–Au I Catalyst
Author(s) -
Tarigopula Chandrahas,
Thota Ganesh Kumar,
Balamurugan Rengarajan
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601025
Subject(s) - chemistry , regioselectivity , cationic polymerization , acetone , catalysis , aldol condensation , solvent , organic chemistry , ketone , medicinal chemistry , condensation , polymer chemistry , physics , thermodynamics
Regioselective hydration of α‐alkynyl esters and ketones by using a cationic NHC–Au I catalyst results in β‐keto esters and β‐diketones, respectively. Controlled release of water in acetone by aldol self‐condensation under the reaction conditions makes acetone as better solvent than 1,4‐dioxane/water for the hydration of α‐alkynyl esters having sensitive ester moieties.