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A Brønsted Acid–Primary Amine as a Synergistic Catalyst for Stereoselective Asymmetric Diels–Alder Reactions
Author(s) -
Ramachary Dhevalapally B.,
Reddy P. Sreekanth,
Shruthi Kodambahalli S.,
Madhavachary R.,
Reddy P. V. Govardhana
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601011
Subject(s) - chemistry , stereoselectivity , brønsted–lowry acid–base theory , primary (astronomy) , amine gas treating , catalysis , organic chemistry , diels–alder reaction , acid catalysis , physics , astronomy
Herein, we present the Brønsted‐acid‐controlled, primary‐amine‐catalyzed stereoselective asymmetric synthesis of druglike six‐membered spirooxindoles from simple aliphatic substrates through a Barbas [4+2]‐cycloaddition reaction by using 2‐aminobuta‐1,3‐diene catalysis under ambient conditions.