Synthesis of Polysubstituted Pyrroles through the Tandem 1,3‐Addition/5‐ endo ‐ dig  Cyclization of 1‐(1‐Alkynyl)cyclopropyl Imines | Zendy

Urbanaitė Aurelija | Zendy; Čikotienė Inga | Zendy

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Synthesis of Polysubstituted Pyrroles through the Tandem 1,3‐Addition/5‐ endo ‐ dig Cyclization of 1‐(1‐Alkynyl)cyclopropyl Imines

Author(s) -

Urbanaitė Aurelija,

Čikotienė Inga

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600985

Subject(s) - chemistry , pyrrole , chalcogen , dig , halogen , ring (chemistry) , synthon , medicinal chemistry , halogen bond , azide , tandem , stereochemistry , combinatorial chemistry , organic chemistry , alkyl , materials science , computer security , computer science , composite material

Cyclopropyl‐tethered 3‐alkynyl imines react with polarized‐covalent‐bond‐containing compounds to give polyfunctionalized pyrroles. This provides a mild and effective method for the simultaneous introduction of halogen, chalcogen, or hydrogen groups to the 3‐position of the pyrrole ring, together with the incorporation of halogen, azide, or alkoxy/aryloxy groups into the ethyl side‐chain.

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