Synthesis of 1,3,6‐Trisubstituted Azulenes Based on the 1‐Acyloxyazulene Scaffold | Zendy

Leino Teppo O. | Zendy; Johansson Niklas G. | Zendy; Devisscher Lars | Zendy; Sipari Nina | Zendy; YliKauhaluoma Jari | Zendy; Wallén Erik A. A. | Zendy

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Synthesis of 1,3,6‐Trisubstituted Azulenes Based on the 1‐Acyloxyazulene Scaffold

Author(s) -

Leino Teppo O.,

Johansson Niklas G.,

Devisscher Lars,

Sipari Nina,

YliKauhaluoma Jari,

Wallén Erik A. A.

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600962

Subject(s) - azulene , chemistry , ring (chemistry) , scaffold , combinatorial chemistry , halogen , stereochemistry , organic chemistry , medicine , alkyl , biomedical engineering

An efficient synthetic route to 1,3,6‐trisubstituted azulenes based on the 1‐acyloxyazulene scaffold was developed. The 1‐position in azulene was substituted in the ring‐formation step with a functionalized acyloxy group. Additionally, the 3‐ and 6‐positions of azulene were functionalized with versatile synthetic handles, a halogen atom and a formyl group.

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