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Synthesis of 1,3,6‐Trisubstituted Azulenes Based on the 1‐Acyloxyazulene Scaffold
Author(s) -
Leino Teppo O.,
Johansson Niklas G.,
Devisscher Lars,
Sipari Nina,
YliKauhaluoma Jari,
Wallén Erik A. A.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600962
Subject(s) - azulene , chemistry , ring (chemistry) , scaffold , combinatorial chemistry , halogen , stereochemistry , organic chemistry , medicine , alkyl , biomedical engineering
An efficient synthetic route to 1,3,6‐trisubstituted azulenes based on the 1‐acyloxyazulene scaffold was developed. The 1‐position in azulene was substituted in the ring‐formation step with a functionalized acyloxy group. Additionally, the 3‐ and 6‐positions of azulene were functionalized with versatile synthetic handles, a halogen atom and a formyl group.