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Synthesis of Fluoroalkyl Pyrazoles from In‐Situ‐Generated C 2 F 5 CHN 2 and Electron‐Deficient Alkenes
Author(s) -
Mykhailiuk Pavel K.,
Ishchenko Aleksandr Yu.,
Stepanenko Viatcheslav,
Cossy Janine
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600947
Subject(s) - chemistry , in situ , cycloaddition , electron , medicinal chemistry , organic chemistry , catalysis , quantum mechanics , physics
C 2 F 5 ‐substituted pyrazolines were synthesized by [3+2]‐cycloaddition between in‐situ‐generated C 2 F 5 CHN 2 and electron‐deficient alkenes. The addition of DBU led to the elimination of HF to give CF 3 CHF‐substituted pyrazoles. Depending on the structure of the pyrazolines, different products were obtained.