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General and Direct Synthesis of Indolizine‐1‐carbaldehydes by 1,3‐Dipolar Cycloaddition of Phenylpropiolaldehyde with Pyridinium Ylides
Author(s) -
Gao Tao,
Chen Xiuling,
Jiang Longqiang,
Wu Minghu,
Guo Haibing,
Wang Jian,
Sun Shaofa,
Oiler Jeremy,
Xing Yalan
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600945
Subject(s) - indolizine , pyridinium , chemistry , scope (computer science) , cycloaddition , substrate (aquarium) , combinatorial chemistry , 1,3 dipolar cycloaddition , organic chemistry , catalysis , computer science , oceanography , programming language , geology
An efficient and one‐step synthesis of indolizine‐1‐carbaldehydes from phenylpropiolaldehyde and pyridinium ylides was developed. The elegant methodology afforded functionalized indolizines with easy operation under mild reaction conditions and with wide substrate scope.