Facile Entry to 3,4‐Dihydro‐1 H ‐pyrrolo[2,1‐ c ][1,4]oxazines through the  oxa ‐Pictet–Spengler Reaction | Zendy

Reddy Chada Raji | Zendy; Burra Amarender Goud | Zendy; Singarapu Kiran K. | Zendy; Grée René | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Facile Entry to 3,4‐Dihydro‐1 H ‐pyrrolo[2,1‐ c ][1,4]oxazines through the oxa ‐Pictet–Spengler Reaction

Author(s) -

Reddy Chada Raji,

Burra Amarender Goud,

Singarapu Kiran K.,

Grée René

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600928

Subject(s) - oxazines , aldehyde , chemistry , ketone , intermolecular force , catalysis , carbon fibers , medicinal chemistry , organic chemistry , molecule , mathematics , composite number , algorithm

An intermolecular approach to the construction of 3,4‐dihydro‐1 H ‐pyrrolo[2,1‐ c ][1,4]oxazines is reported for the first time using the oxa ‐Pictet–Spengler reaction. The method involves a sequence of carbon–carbon‐ and carbon–oxygen‐bond formation between a substituted 2‐(1 H ‐pyrrol‐1‐yl)ethan‐1‐ol and an aldehyde/ketone. p ‐Toluenesulfonic acid ( p TSA) was identified as a suitable catalyst to promote the reaction. The method provides a one‐step conversion of various aldehydes/ketones into the corresponding 3,4‐dihydro‐1 H ‐pyrrolo[2,1‐ c ][1,4]oxazines.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research