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Cu/Ag‐Cocatalyzed Aerobic Oxidative Amination and CuCl 2 ‐Mediated Aerobic Oxidative Chloroamination of Maleimides
Author(s) -
An YuLong,
Zhang HeHui,
Yang ZhenHua,
Lin Long,
Zhao ShengYin
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600923
Subject(s) - chemistry , amination , oxidative phosphorylation , primary (astronomy) , organic chemistry , medicinal chemistry , photochemistry , catalysis , biochemistry , physics , astronomy
An efficient Cu(OAc) 2 /Ag 2 CO 3 ‐cocatalyzed approach for the synthesis of 3‐aminomaleimides and 3‐amino‐4‐indolylmaleimides has been developed with satisfactory yields. A series of primary and secondary amines are compatible with this reaction. In addition, treatment of maleimides with primary amines using 1 equiv. of CuCl 2 leads to the formation of chloroamination products such as 3‐amino‐4‐chloromaleimides by a radical‐type mechanism.