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Copper‐Catalyzed Cross‐Dehydrogenative Coupling of N ‐Iminoquinolinium Ylides with Secondary Amines
Author(s) -
Hua Zerui,
Fang Lei,
Wu Shengying,
Wang Limin
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600905
Subject(s) - chemistry , amination , catalysis , regioselectivity , ligand (biochemistry) , quinoline , combinatorial chemistry , copper , medicinal chemistry , base (topology) , organic chemistry , mathematical analysis , biochemistry , receptor , mathematics
The copper‐catalyzed cross‐dehydrogenative coupling of N ‐iminoquinolinium ylides with secondary amines led to ortho ‐amino‐substituted quinoline derivatives with high levels of regioselectivity in good yields. This direct C–H bond amination transformation employs CuI as the catalyst without the use of a ligand, external oxidant, or base. The reaction is operationally simple and can be conducted under mild conditions. The N ‐benzoyl directing group can be removed without any additional steps.