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A Cascade C–H‐Functionalization/Cyclization Reaction of Indoles with α‐Halo or α‐Sulfonyloxy Ketones for the Synthesis of Dihydropyrimidoindolone Derivatives
Author(s) -
Wu ZiJun,
Li YaQiong,
Huang ZhiZhen
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600885
Subject(s) - chemistry , surface modification , cascade , rhodium , catalysis , cascade reaction , combinatorial chemistry , halo , medicinal chemistry , stereochemistry , organic chemistry , physics , chromatography , quantum mechanics , galaxy
A new cascade C–H‐functionalization/cyclization reaction of N ‐carbamoylindoles 1 with α‐halo, α‐mesyloxy, or α‐tosyloxy ketones 2 has been developed under rhodium(III) catalysis, leading to dihydropyrimido[1,6‐ a ]indolone derivatives 3 in moderate to excellent yields.