A Cascade C–H‐Functionalization/Cyclization Reaction of Indoles with α‐Halo or α‐Sulfonyloxy Ketones for the Synthesis of Dihydropyrimidoindolone Derivatives | Zendy

Wu ZiJun | Zendy; Li YaQiong | Zendy; Huang ZhiZhen | Zendy

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A Cascade C–H‐Functionalization/Cyclization Reaction of Indoles with α‐Halo or α‐Sulfonyloxy Ketones for the Synthesis of Dihydropyrimidoindolone Derivatives

Author(s) -

Wu ZiJun,

Li YaQiong,

Huang ZhiZhen

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600885

Subject(s) - chemistry , surface modification , cascade , rhodium , catalysis , cascade reaction , combinatorial chemistry , halo , medicinal chemistry , stereochemistry , organic chemistry , physics , chromatography , quantum mechanics , galaxy

A new cascade C–H‐functionalization/cyclization reaction of N ‐carbamoylindoles 1 with α‐halo, α‐mesyloxy, or α‐tosyloxy ketones 2 has been developed under rhodium(III) catalysis, leading to dihydropyrimido[1,6‐ a ]indolone derivatives 3 in moderate to excellent yields.

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