Premium
First Tandem‐Type One‐Pot Process Combining Asymmetric Organo‐ and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3‐Diols
Author(s) -
Rulli Giuseppe,
Duangdee gnaphat,
Hummel Werner,
Berkessel Albrecht,
Gröger Harald
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600831
Subject(s) - chemistry , enantioselective synthesis , tandem , aldol reaction , aqueous medium , aldehyde , one pot synthesis , substrate (aquarium) , combinatorial chemistry , aqueous solution , organic chemistry , biocatalysis , organocatalysis , catalysis , reaction mechanism , materials science , oceanography , composite material , geology
A suitable “process window” was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio‐ and diastereoselective synthesis of 1,3‐diols in a tandem‐type, one‐pot process. A key feature of this one‐pot synthesis is the high 500 m m loading of the aldehyde substrate used as a starting material.