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Transition‐Metal‐Free Cross‐Coupling Reactions in Dynamic Thin Films To Access Pyrimidine and Quinoxaline Analogues
Author(s) -
Ho Louisa A.,
Raston Colin L.,
Stubbs Keith A.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600830
Subject(s) - quinoxaline , chemistry , transition metal , borosilicate glass , pyrimidine , microfluidics , yield (engineering) , coupling reaction , catalysis , nanotechnology , chemical engineering , polymer chemistry , chemical physics , organic chemistry , stereochemistry , composite material , materials science , engineering
The vortex fluidic device (VFD) is effective in modulating the synthesis of pyrimidine and quinoxaline‐based compounds at room temperature and in high yield. The formation of the C–N bond occurs in the absence of a transition‐metal catalyst, which avoids the contamination of the products with trace amounts of a transition metal. The systematic investigation of the operating parameters for the microfluidic platform in the confined operation mode established an optimum tilt angle of 45° for a 10 mm diameter borosilicate glass tube rotating at 5000 rpm.