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Organocatalytic α‐Allylation of α‐Branched Aldehydes by Synergistic Catalysis of Brønsted Acids and Amines
Author(s) -
Stanek Filip,
Stodulski Maciej
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600725
Subject(s) - chemistry , brønsted–lowry acid–base theory , catalysis , organic chemistry , organocatalysis , aldehyde , enantioselective synthesis
Herein, we describe the first, fully organocatalytic Tsuji–Trost‐type direct α‐allylation of α‐branched aldehydes by the combined use of N ‐triflyl amides and secondary amines. Aliphatic, aromatic aldehydes as well as allyl alcohols are converted into the corresponding α‐allylated products in moderate to high yields.