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Selective gem ‐Dichlorination of Isonitriles Mediated by (Dichloroiodo)benzene
Author(s) -
Zhang Haifeng,
Shi Dongdong,
Ren Shaobo,
Jin Hongwei,
Liu Yunkui
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600667
Subject(s) - chemistry , benzophenone , reagent , benzene , imine , combinatorial chemistry , organic chemistry , medicinal chemistry , benzene derivatives , chemical synthesis , catalysis , biochemistry , in vitro
A selective gem ‐dichlorination of isonitriles has been successfully achieved by using (dichloroiodo)benzene as a chlorinating reagent. The reaction gives N ‐arylcarbonimidic dichlorides in high yields under mild and metal‐free conditions. The application of N ‐arylcarbonimidic dichlorides as synthetic intermediates in the synthesis of 2,2,3,3‐tetrachloroaziridine 4 , propyl formimidate 5 , benzophenone imine 6 , and 6‐chlorophenanthridine ( 3a ) was also investigated.