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Palladium‐Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives with K 4 [Fe(CN) 6 ] by C–H Bond Activation
Author(s) -
Kianmehr Ebrahim,
Faghih Nasser,
Tanbakouchian Arezoo,
Mahdavi Mohammad
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600618
Subject(s) - cyanation , regioselectivity , acetanilide , chemistry , palladium , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
A practical, versatile, and efficient method for the palladium‐catalyzed direct cyanation of readily available acetanilides with K 4 [Fe(CN) 6 ] as a safe cyanating agent through C–H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N ‐(2‐cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals.