Palladium‐Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives with K 4 [Fe(CN) 6 ] by C–H Bond Activation | Zendy

Kianmehr Ebrahim | Zendy; Faghih Nasser | Zendy; Tanbakouchian Arezoo | Zendy; Mahdavi Mohammad | Zendy

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Palladium‐Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives with K 4 [Fe(CN) 6 ] by C–H Bond Activation

Author(s) -

Kianmehr Ebrahim,

Faghih Nasser,

Tanbakouchian Arezoo,

Mahdavi Mohammad

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600618

Subject(s) - cyanation , regioselectivity , acetanilide , chemistry , palladium , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry

A practical, versatile, and efficient method for the palladium‐catalyzed direct cyanation of readily available acetanilides with K 4 [Fe(CN) 6 ] as a safe cyanating agent through C–H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N ‐(2‐cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals.

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