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A General CuCl 2 ‐Promoted Alkene Aminochlorination Reaction
Author(s) -
Li ShuQi,
Xiong Peng,
Zhu Lin,
Qian XiangYang,
Xu HaiChao
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600589
Subject(s) - alkene , chemistry , vicinal , moiety , chloride , reaction mechanism , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis
A CuCl 2 ‐promoted alkene aminochlorination reaction has been developed. A variety of anilides that contain a mono‐, di‐, or trisubstituted alkenyl moiety readily participated in this reaction to afford structurally diverse vicinal chloroamines. Studies suggest that the process proceeds by a radical‐type mechanism and that CuCl 2 serves as both the oxidant to generate the amidyl radical as well as the chloride source.