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Air‐Assisted 2‐Oxo‐Driven Dehydrogenative α,α‐Diamination of 2‐Oxo Aldehydes to 2‐Oxo Acetamidines
Author(s) -
Kumar Atul,
Battini Narsaiah,
Kumar Raju Ranjith,
Athimoolam S.,
Ahmed Qazi Naveed
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600587
Subject(s) - chemistry , dehydrogenation , component (thermodynamics) , transformation (genetics) , functional group , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , physics , polymer , gene , thermodynamics
An air‐assisted, functional‐group‐driven, mild, additive‐free, three‐component synthetic approach to different 2‐oxo acetamidines from 2‐oxo aldehydes, secondary amines, and anilines was successfully developed. Mechanistically, the transformation proceeds through a highly unstable system (RCOCHN 1 N 2 ) that rearranges at room temperature and undergoes air‐assisted dehydrogenation to different 2‐oxo acetamidines.