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Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent
Author(s) -
Toure Momar,
JaimeFigueroa Saul,
Burslem George M.,
Crews Craig M.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600575
Subject(s) - isocoumarins , chemistry , acetylene , isocoumarin , borane , organic chemistry , combinatorial chemistry , catalysis
An innovative and simple expeditious synthesis of 3,4‐unsubstituted isoquinolones and isocoumarins starting from a safe and easy‐to‐handle two‐carbon acetylene equivalent was developed. The synthetic potential of this new method was further demonstrated in the facile total synthesis of two naturally occurring alkaloids, corydaldine and doryanine.