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A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase‐Transfer Catalyst
Author(s) -
Hiramatsu Kenichi,
Tamamura Hirokazu
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600570
Subject(s) - chemistry , selectfluor , catalysis , organic chemistry , phosphoric acid , phase (matter) , solvent , base (topology) , organocatalysis , combinatorial chemistry , enantioselective synthesis , mathematical analysis , mathematics
A mild fluorination method for pyrroles, based on anionic phase‐transfer catalysis by using Selectfluor, a lipophilic phosphoric acid, and a base in an apolar solvent is described. The thus obtained fluorinated pyrroles bearing a wide variety of functional groups are attractive building blocks for medicinal chemistry.