A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase‐Transfer Catalyst | Zendy

Hiramatsu Kenichi | Zendy; Tamamura Hirokazu | Zendy

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A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase‐Transfer Catalyst

Author(s) -

Hiramatsu Kenichi,

Tamamura Hirokazu

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600570

Subject(s) - chemistry , selectfluor , catalysis , organic chemistry , phosphoric acid , phase (matter) , solvent , base (topology) , organocatalysis , combinatorial chemistry , enantioselective synthesis , mathematical analysis , mathematics

A mild fluorination method for pyrroles, based on anionic phase‐transfer catalysis by using Selectfluor, a lipophilic phosphoric acid, and a base in an apolar solvent is described. The thus obtained fluorinated pyrroles bearing a wide variety of functional groups are attractive building blocks for medicinal chemistry.

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