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An Efficient Multi‐Component Synthesis of Highly Functionalized Calix[4]arenes with Pronounced Binding Affinity toward β‐Lactoglobulin
Author(s) -
Zadmard Reza,
AkbariMoghaddam Peyman,
Darvishi Shukufe,
MirzaAghayan Maryam
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600543
Subject(s) - chemistry , calixarene , combinatorial chemistry , component (thermodynamics) , fluorescence , reaction conditions , organic chemistry , molecule , catalysis , physics , quantum mechanics , thermodynamics
A facile and convenient approach for the synthesis of multi‐functionalized calix[4]arenes through multi‐component reactions is described. A series of five new calix[4]arene‐hexaamide derivatives were synthesized, and their structures were elucidated by means of spectroscopic data. The value of this method lies in its operational simplicity, mild reaction conditions, structural diversity of products, and good yields. Furthermore, fluorescence studies demonstrated considerable binding affinity of these new calix[4]arenes toward β‐lactoglobulin protein.