Palladium‐Catalyzed Regioselective C–H Acetoxylation of 2‐Aryloxypyridines with 2‐Pyridyloxy as a Removable Directing Group | Zendy

Wang Liang | Zendy; Pan Liang | Zendy; Huang Yibo | Zendy; Chen Qun | Zendy; He Mingyang | Zendy

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Palladium‐Catalyzed Regioselective C–H Acetoxylation of 2‐Aryloxypyridines with 2‐Pyridyloxy as a Removable Directing Group

Author(s) -

Wang Liang,

Pan Liang,

Huang Yibo,

Chen Qun,

He Mingyang

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600508

Subject(s) - regioselectivity , palladium , chemistry , catalysis , phenols , medicinal chemistry , stereochemistry , organic chemistry , combinatorial chemistry

A simple and regioselective palladium‐catalyzed ortho ‐C(sp 2 )–H acetoxylation of 2‐aryloxypyridines with PhI(OAc) 2 as both the oxidant and acetate source has been developed. The mono‐ and di‐acetoxylated products can be achieved by tuning the equivalents of PhI(OAc) 2 and the reaction temperature. A wide range of 2‐aryloxypyridines is tolerated. Moreover, 2‐pyridyloxyl and acetyl groups can be easily removed, which provides straightforward access to poly‐substituted phenols.

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