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Ruthenium‐Catalyzed C–H Amidation and Alkenylation of Cyclic N ‐Sulfonyl Ketimines
Author(s) -
Manoharan Ramasamy,
Jeganmohan Masilamani
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600505
Subject(s) - sulfonyl , chemistry , ruthenium , catalysis , regioselectivity , medicinal chemistry , amination , organic chemistry , alkyl
A highly regioselective ruthenium‐catalyzed C–H amidation of cyclic N ‐sulfonyl ketimines with organic sulfonyl azides is described. An alkenylation at the C–H bond of cyclic N ‐sulfonyl ketimines with various alkenes was also carried out. Only a catalytic amount of the oxidant Cu(OAc) 2 was used in the reaction; the remainder of the required amount of oxidant was formed by regeneration of Cu(OAc) 2 under an air atmosphere.