Highly Efficient and Practical Thiocyanation of Imidazopyridines Using an  N ‐Chlorosuccinimide/NaSCN Combination | Zendy

Zhang Hailei | Zendy; Wei Qian | Zendy; Wei Shiqiang | Zendy; Qu Jingping | Zendy; Wang Baomin | Zendy

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Highly Efficient and Practical Thiocyanation of Imidazopyridines Using an N ‐Chlorosuccinimide/NaSCN Combination

Author(s) -

Zhang Hailei,

Wei Qian,

Wei Shiqiang,

Qu Jingping,

Wang Baomin

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600485

Subject(s) - chemistry , environmentally friendly , functional group , reaction conditions , combinatorial chemistry , green chemistry , condensation , organic chemistry , reaction mechanism , catalysis , ecology , physics , thermodynamics , biology , polymer

A direct C–H thiocyanation of imidazo[1,2‐ a ]pyridines, and a practical sequential one‐pot condensation/C–H thiocyanation process, using a combination of N ‐chlorosuccinimide/NaSCN for the synthesis of 3‐thiocyanatoimidazo[1,2‐ a ]pyridines have been developed. The reactions are environmentally friendly, and easy to carry out. They use readily available starting materials and mild reaction conditions, show a wide functional group tolerance, and give good to excellent yields.

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