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Highly Efficient and Practical Thiocyanation of Imidazopyridines Using an N ‐Chlorosuccinimide/NaSCN Combination
Author(s) -
Zhang Hailei,
Wei Qian,
Wei Shiqiang,
Qu Jingping,
Wang Baomin
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600485
Subject(s) - chemistry , environmentally friendly , functional group , reaction conditions , combinatorial chemistry , green chemistry , condensation , organic chemistry , reaction mechanism , catalysis , ecology , physics , thermodynamics , biology , polymer
A direct C–H thiocyanation of imidazo[1,2‐ a ]pyridines, and a practical sequential one‐pot condensation/C–H thiocyanation process, using a combination of N ‐chlorosuccinimide/NaSCN for the synthesis of 3‐thiocyanatoimidazo[1,2‐ a ]pyridines have been developed. The reactions are environmentally friendly, and easy to carry out. They use readily available starting materials and mild reaction conditions, show a wide functional group tolerance, and give good to excellent yields.