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Glycosylation via Transition‐Metal Catalysis: Challenges and Opportunities
Author(s) -
Li Xiaohua,
Zhu Jianglong
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600484
Subject(s) - glycoconjugate , chemistry , stereoselectivity , glycosylation , transition metal , combinatorial chemistry , catalysis , glycoside , stereochemistry , organic chemistry , biochemistry
Development of efficient, mild, and easily operable stereoselective glycosylations is of critical importance to access sufficient amounts of pure and structurally well‐defined carbohydrates for studies of their biological functions. Such studies will facilitate our understanding of the role of complex oligosaccharides and glycoconjugates in biological processes as well as the development of carbohydrate‐based effective therapeutic agents. This review highlights recent advances in the transition metal catalyzed stereoselective glycosylations for the synthesis of a variety of structurally complex and biologically significant O ‐, N ‐, C ‐, and S ‐glycosides.