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Regioselective ortho ‐Acylation of N ‐Aryl‐1,2,3‐triazoles with Alcohols in Water
Author(s) -
Premi Chanchal,
Patel Shyam Sunder,
Jain Nidhi
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600479
Subject(s) - chemistry , regioselectivity , acylation , aryl , reagent , organic chemistry , aqueous solution , palladium , catalysis , medicinal chemistry , combinatorial chemistry , alkyl
A palladium‐catalyzed regioselective ortho ‐acylation of N ‐aryl‐1,2,3‐triazoles has been achieved under aqueous conditions without the assistance of surfactants or additives. The reaction takes place by using benzylic, heterocyclic, and aliphatic alcohols as the acylating reagents and tert ‐butyl hydroperoxide (TBHP) as the oxidant and provides an alternative route for the synthesis of triazole‐substituted aryl, heteroaryl, and aliphatic ketones in moderate to excellent yields.