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A General and Mild Copper(I)‐Catalyzed Three‐Component Reaction of Cyanamides, Amines, and Diaryliodonium Triflates
Author(s) -
Li Jihui,
Wang Hongxing,
Hou Yifeng,
Yu Weiguang,
Xu Shuying,
Zhang Yucang
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600332
Subject(s) - chemistry , catalysis , copper , reaction conditions , component (thermodynamics) , combinatorial chemistry , functional group , organic chemistry , physics , polymer , thermodynamics
A highly efficient copper‐catalyzed three‐component reaction of cyanamides, amines, and diaryliodonium triflates was developed for the synthesis of guanidines. The mild reaction accommodates both aromatic and aliphatic amines and provides the products in good yields with good functional group tolerance. Moreover, it was demonstrated that C–H activation of the arenes could be realized for the direct preparation of guanidines.