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DBU‐Mediated [3+2] Cycloaddition Reactions of Donor–Acceptor Cyclopropanes with Nitromethane: Efficient Strategy for the Construction of Isoxazole Skeletons
Author(s) -
Xue Shuwen,
Liu Jiaming,
Wang Cunde
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600227
Subject(s) - nitromethane , isoxazole , chemistry , cycloaddition , acceptor , combinatorial chemistry , organic chemistry , computational chemistry , catalysis , physics , condensed matter physics
A new DBU‐mediated [3+2] cycloaddition reaction has been developed using readily available donor–acceptor cyclopropanes and nitromethane. This approach provides a straightforward and efficient route to the construction of polysubstituted isoxazole scaffolds in high yields.

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