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Metal‐Free Direct Dehydroxytrifluoromethylthiolation of Alcohols via the Umpolung Reactivity of Trifluoromethanesulfenamides
Author(s) -
Glenadel Quentin,
Tlili Anis,
Billard Thierry
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600197
Subject(s) - umpolung , chemistry , reactivity (psychology) , metal , organic chemistry , combinatorial chemistry , catalysis , nucleophile , medicine , alternative medicine , pathology
A direct dehydroxytrifluoromethylthiolation of alcohols with trifluoromethanesulfenamide has been described. This method, based on the original umpolung reactivity of trifluoromethanesulfenamides, proposes a direct “OH‐SCF 3 exchange” under mild and, more especially, metal‐free conditions.