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Time‐Efficient Synthesis of Pyrido[2,3‐ d ]pyrimidinones via α‐Oxoketenes
Author(s) -
Castillo JuanCarlos,
Quiroga Jairo,
Rodriguez Jean,
Coquerel Yoann
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600171
Subject(s) - chemistry , pyrimidinones , nucleophile , yield (engineering) , surface modification , diazo , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , materials science , metallurgy , catalysis
α‐Oxoketene reactive intermediates generated in situ by microwave‐assisted Wolff rearrangement of 2‐diazo‐1,3‐dicarbonyl compounds have been found to react with 6‐aminopyrimidine derivatives as 1,3‐C,N‐bis‐nucleophiles to yield pyrido[2,3‐ d ]pyrimidinones and related compounds amenable to further functionalization.