Time‐Efficient Synthesis of Pyrido[2,3‐ d ]pyrimidinones via α‐Oxoketenes | Zendy

Castillo JuanCarlos | Zendy; Quiroga Jairo | Zendy; Rodriguez Jean | Zendy; Coquerel Yoann | Zendy

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Time‐Efficient Synthesis of Pyrido[2,3‐ d ]pyrimidinones via α‐Oxoketenes

Author(s) -

Castillo JuanCarlos,

Quiroga Jairo,

Rodriguez Jean,

Coquerel Yoann

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600171

Subject(s) - chemistry , pyrimidinones , nucleophile , yield (engineering) , surface modification , diazo , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , materials science , metallurgy , catalysis

α‐Oxoketene reactive intermediates generated in situ by microwave‐assisted Wolff rearrangement of 2‐diazo‐1,3‐dicarbonyl compounds have been found to react with 6‐aminopyrimidine derivatives as 1,3‐C,N‐bis‐nucleophiles to yield pyrido[2,3‐ d ]pyrimidinones and related compounds amenable to further functionalization.

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