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Rare Sesquiterpenoids from the Shed Trunk Barks of the Critically Endangered Plant Abies beshanzuensis and Their Bioactivities
Author(s) -
Hu ChangLing,
Xiong Juan,
Li JiYang,
Gao LiXin,
Wang WenXuan,
Cheng KeJun,
Yang GuoXun,
Li Jia,
Hu JinFeng
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600165
Subject(s) - chemistry , circular dichroism , epimer , stereochemistry , terpene , botany , biology
Two rare rearranged cuparane‐type sesquiterpenoid C‐10 epimers [beshanzuenones A ( 1 ) and B ( 2 )] and two bisabolane‐type sesquiterpenoid spirolactones [beshanzuenones C ( 3 ) and D ( 4 )] featuring an unusual [6/6/5]‐fused tricyclic ring system were isolated from the shed trunk barks of Abies beshanzuensis , one of the critically endangered plant species in the world. The structures of these four new enone‐containing sesquiterpenoids were determined by spectroscopic analyses and single‐crystal X‐ray diffraction or electronic circular dichroism (ECD) calculations. Compounds 1 and 2 showed considerable activity against the H3N2 virus, whereas 3 and 4 exhibited significant inhibition on PTP1B.