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Exploration of the Bis(thio)urea‐Catalyzed Atropselective Synthesis of Marinopyrrole A
Author(s) -
Stodulski Maciej,
Kohlhepp Stefanie V.,
Raabe Gerhard,
Gulder Tanja
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600147
Subject(s) - chemistry , thio , catalysis , combinatorial chemistry , urea , organic chemistry
The marinopyrroles are a new class of natural products with highly interesting biomedical and structural features. We herein provide a concise, nitrogen‐protective‐group‐free synthesis of marinopyrrole A, constituting the as yet most efficient route. The presented studies elaborate a straightforward and mild chlorination protocol. Moreover, the first study towards the atropselective synthesis of marinopyrrole A, using chiral, C 2 ‐symmetric bisthiourea catalysts, is presented.