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Ligand‐ and Metal‐Driven Selection of Flexible Adaptive Dynamic Host Receptors
Author(s) -
Zhang Yan,
Legrand YvesMarie,
van der Lee Arie,
Barboiu Mihail
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600126
Subject(s) - chemistry , ligand (biochemistry) , selection (genetic algorithm) , crystallization , metal , metal ions in aqueous solution , nanotechnology , combinatorial chemistry , receptor , computer science , materials science , organic chemistry , biochemistry , artificial intelligence
Chemical synthesis by design can produce a vast number of molecular structures, while dynamic constitutional synthesis by selection, leads to unexpected structures. The use of flexible components and a high number of bonds, usually gives access to polymeric systems or to unpredictable structures. For this reason, we prepared dynamic mixtures in which a reversibly binding trialdehyde and flexible PEG diamine building blocks assemble in the presence of or absence of templating metal ions. The dynamic exchanges in solution are robust enough to induce “ligand selection” with the formation of a cage and the precise quantitative “Ag + ‐driven” selection with the formation of an interlocked cage and a twisted cage, amplified from the solution by a kinetically driven crystallization process.