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Exploring the Complexity‐Generating Features of the Pauson–Khand Reaction from a Synthetic Perspective
Author(s) -
Shi Lili,
Yang Zhen
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600123
Subject(s) - pauson–khand reaction , cyclopentenone , chemistry , stereocenter , alkyne , alkene , total synthesis , carbon monoxide , combinatorial chemistry , molecule , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , intramolecular force
The Pauson–Khand reaction (PKR) is used to construct a cyclopentenone framework from an alkene, an alkyne, and carbon monoxide, through a domino sequence of bond constructions. This microreview covers the synthetic application of the PKR in the total synthesis of a collection of structurally challenging natural products in the authors' laboratory over the past 10 years, beautifully exploring the complexity‐generating features of the PKR. Key to the success of these total syntheses is the implementation of the PKR to access complex target molecules containing numerous stereocenters.