Tandem Demethylation/Annulation/Oxidation of 2,3‐Bis(2‐methoxyphenyl)‐3‐oxopropanals for One‐Pot Construction of Coumestans | Zendy

Zhang Jiefeng | Zendy; Qiu Jiakun | Zendy; Xiao Chunmei | Zendy; Yu Lifang | Zendy; Yang Fan | Zendy; Tang Jie | Zendy

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Tandem Demethylation/Annulation/Oxidation of 2,3‐Bis(2‐methoxyphenyl)‐3‐oxopropanals for One‐Pot Construction of Coumestans

Author(s) -

Zhang Jiefeng,

Qiu Jiakun,

Xiao Chunmei,

Yu Lifang,

Yang Fan,

Tang Jie

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600122

Subject(s) - annulation , chemistry , demethylation , tandem , stereochemistry , combinatorial chemistry , sequence (biology) , organic chemistry , biochemistry , gene expression , materials science , dna methylation , composite material , gene , catalysis

A convenient and practical approach to coumestans has been successfully developed by using a one‐pot tandem demethylation/annulation/oxidation reaction sequence that employs easily accessible 2,3‐bis(2‐methoxyphenyl)‐3‐oxopropanals as the starting material. This synthetic protocol provided a variety of coumestan derivatives in good to excellent yields under mild conditions. The exploration of biologically active coumestan compounds is a potential application of this synthetic method.

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