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Tandem Demethylation/Annulation/Oxidation of 2,3‐Bis(2‐methoxyphenyl)‐3‐oxopropanals for One‐Pot Construction of Coumestans
Author(s) -
Zhang Jiefeng,
Qiu Jiakun,
Xiao Chunmei,
Yu Lifang,
Yang Fan,
Tang Jie
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600122
Subject(s) - annulation , chemistry , demethylation , tandem , stereochemistry , combinatorial chemistry , sequence (biology) , organic chemistry , biochemistry , gene expression , materials science , dna methylation , composite material , gene , catalysis
A convenient and practical approach to coumestans has been successfully developed by using a one‐pot tandem demethylation/annulation/oxidation reaction sequence that employs easily accessible 2,3‐bis(2‐methoxyphenyl)‐3‐oxopropanals as the starting material. This synthetic protocol provided a variety of coumestan derivatives in good to excellent yields under mild conditions. The exploration of biologically active coumestan compounds is a potential application of this synthetic method.