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Sequential, One‐Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols
Author(s) -
Jiang JiaHeng,
Boominathan Siva Senthil Kumar,
Hu WanPing,
Chen ChungYu,
Vandavasi Jaya Kishore,
Lin YingTing,
Wang JehJeng
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600119
Subject(s) - chemistry , phenols , triflic acid , catalysis , organic chemistry , combinatorial chemistry
A sequential one‐pot approach towards arylated benzoquinones and naphthoquinones is reported. The reaction proceeds through oxidation of phenols/naphthols followed by CH‐arylation with a catalytic amount of triflic acid. Preliminary cytotoxic studies were carried out with five different cell lines and some of the compounds show promising activity.