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Copper‐Catalyzed Oxidative Synthesis of Sulfinamides Using Thiols or Disulfides with Amines
Author(s) -
Taniguchi Nobukazu
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600091
Subject(s) - chemistry , catalysis , copper , oxidative phosphorylation , oxidative coupling of methane , reaction conditions , combinatorial chemistry , organic chemistry , biochemistry
Copper‐catalyzed coupling of thiols with amines was used to synthesize numerous sulfinamides in excellent yields. Sulfenamides or sulfonamides were also formed as reaction byproducts albeit in trace quantities. The procedure is carried out as a one step and was found to be promoted by the addition of water and NH 4 PF 6 under aerobic conditions. Furthermore, the reaction proceeds smoothly when using disulfides. Consequently, it is clear that both thiols and disulfides are useful S‐sources under these reaction conditons.