Direct and Efficient (Carbonyl)cobalt‐Mediated Aryl Acetylation Using [11C]Methyl Iodide | Zendy

Dahl Kenneth | Zendy; Schou Magnus | Zendy; Halldin Christer | Zendy

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Direct and Efficient (Carbonyl)cobalt‐Mediated Aryl Acetylation Using [11C]Methyl Iodide

Author(s) -

Dahl Kenneth,

Schou Magnus,

Halldin Christer

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600085

Subject(s) - chemistry , carbonylation , methyl iodide , aryl , iodide , carbon monoxide , halide , cobalt , labelling , acetylation , combinatorial chemistry , organic chemistry , catalysis , alkyl , biochemistry , gene

A new strategy is reported that allows direct access to 11 C‐labelled aryl methyl ketones by a fast and efficient (carbonyl)cobalt‐mediated protocol employing [ 11 C]methyl iodide as the labelling agent. The method uses Co 2 CO 8 as combined aryl halide activator and carbon monoxide source for the carbonylation reaction. The suitability of the methodology was demonstrated by the 11 C‐labelling of a set of functionalised arenes and heteroarenes with radiochemical conversions (RCC) ranging from 22 % to 63 %.

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