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Direct and Efficient (Carbonyl)cobalt‐Mediated Aryl Acetylation Using [11C]Methyl Iodide
Author(s) -
Dahl Kenneth,
Schou Magnus,
Halldin Christer
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600085
Subject(s) - chemistry , carbonylation , methyl iodide , aryl , iodide , carbon monoxide , halide , cobalt , labelling , acetylation , combinatorial chemistry , organic chemistry , catalysis , alkyl , biochemistry , gene
A new strategy is reported that allows direct access to 11 C‐labelled aryl methyl ketones by a fast and efficient (carbonyl)cobalt‐mediated protocol employing [ 11 C]methyl iodide as the labelling agent. The method uses Co 2 CO 8 as combined aryl halide activator and carbon monoxide source for the carbonylation reaction. The suitability of the methodology was demonstrated by the 11 C‐labelling of a set of functionalised arenes and heteroarenes with radiochemical conversions (RCC) ranging from 22 % to 63 %.