Premium
Cyclative Cascades of Allenamides Derived from Amino Acids: Synthesis of Annulated Indoxyl Derivatives
Author(s) -
Petkovic Milos,
Nasufovic Veselin,
Djukanovic Dimitrije,
Vujosevic Zorana Tokic,
Jadranin Milka,
Matovic Radomir,
Savic Vladimir
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600067
Subject(s) - chemistry , cascade , combinatorial chemistry , amino acid , structural motif , cascade reaction , stereochemistry , catalysis , organic chemistry , biochemistry , chromatography
Allenamides derived from amino acids participate in the cascade transformations catalyzed by Pd 0 allowing consecutive formation of two five‐membered rings. The developed methodology provides an access to annulated indoles which can be transformed to functionalized indoxyl derivatives, retaining a structural motif embedded in several natural products.