GAP Peptide Synthesis through the Design of a GAP Protecting Group: An Fmoc/ t Bu Synthesis of Thymopentin Free from Polymers, Chromatography and Recrystallization | Zendy

Seifert Cole W. | Zendy; Paniagua Armando | Zendy; White Gabrielle A. | Zendy; Cai Lucy | Zendy; Li Guigen | Zendy

Premium

GAP Peptide Synthesis through the Design of a GAP Protecting Group: An Fmoc/ t Bu Synthesis of Thymopentin Free from Polymers, Chromatography and Recrystallization

Author(s) -

Seifert Cole W.,

Paniagua Armando,

White Gabrielle A.,

Cai Lucy,

Li Guigen

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201600026

Subject(s) - chemistry , protecting group , recrystallization (geology) , peptide synthesis , thymopentin , peptide , solid phase synthesis , yield (engineering) , combinatorial chemistry , chromatography , organic chemistry , alkyl , biochemistry , paleontology , materials science , metallurgy , immunology , biology

A novel method for Fmoc/ t Bu solution‐phase peptide synthesis and the development of a new benzyl‐type group‐assisted purification (GAP) protecting group is reported. This GAP protecting group is utilized in place of a polymer support, facilitating C→N Fmoc peptide synthesis without chromatography or recrystallization. The GAP group can be added and removed in high yield, and was used to synthesize over 1 gram of the immunostimulant, thymopentin, in high overall yield (83 %) and purity (99 %).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research