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Conjugation of Bioactive Molecules to a Fluorescent Dithiomaleimide by Photoinduced and BEt 3 ‐Initiated Thio‐Click Reactions (Eur. J. Org. Chem. 35/2015)
Author(s) -
Lázár László,
Nagy Miklós,
Borbás Anikó,
Herczegh Pál,
Zsuga Miklós,
Kéki Sándor
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201590100
Subject(s) - chemistry , maleimide , fluorescence , click chemistry , thio , conjugate , photochemistry , triethylborane , thiol , combinatorial chemistry , coupling reaction , bioconjugation , ether , polymer chemistry , organic chemistry , catalysis , mathematical analysis , physics , mathematics , quantum mechanics
The cover picture shows the coupling of a fluorescent dithiomaleimide bearing a vinyl ether functionality to bioactive compounds through free‐radical hydrothiolation. Out of the photoinduced and triethylborane‐initiated methods applied, the latter was found to be superior for modification of the sensitive maleimide group. All addition products exhibited strong green fluorescence having almost identical absorption and emission spectra, proving that the thiol part has little influence on the fluorescent properties of the conjugates. Details are discussed in the article by S. Kéki et al. on 7675 ff .