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Substrate Activation in the Catalytic Asymmetric Hydrogenation of N ‐Heteroarenes (Eur. J. Org. Chem. 24/2015)
Author(s) -
Balakrishna Bugga,
NúñezRico José Luis,
VidalFerran Anton
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201590067
Subject(s) - chemistry , enantioselective synthesis , substrate (aquarium) , catalysis , aromaticity , combinatorial chemistry , organocatalysis , stereochemistry , organic chemistry , molecule , oceanography , geology
The cover picture shows an artistic interpretation of the proficiency of the activated substrates in hydrogenation by means of different strategies: forming positively charged derivatives of the heteroarene (Strategy I), introducing a ligating group to the substrate to assist its coordination to the metal center (Strategy II), or breaking the aromaticity of the heteroarene by inducing double‐bond migration processes (Strategy III) that have allowed the development of highly enantioselective catalytic hydrogenations of N‐heteroarenes towards fully or partly saturated chiral heterocycles. Details are presented in the Microreview by A. Vidal‐Ferran et al. on 5293 ff .