(Imidazol‐2‐yl)methyl‐1,3‐propanediones: Regioselective C–H Functionalization of the Imidazole Ring by Acylacetylene/Aldehyde Pairs | Zendy

Trofimov Boris A. | Zendy; Andriyankova Ludmila V. | Zendy; Nikitina Lina P. | Zendy; Belyaeva Kseniya V. | Zendy; Mal'kina Anastasiya G. | Zendy; Bagryanskaya Irina Yu. | Zendy; Afonin Andrei V. | Zendy; Ushakov Igor A. | Zendy

Premium

(Imidazol‐2‐yl)methyl‐1,3‐propanediones: Regioselective C–H Functionalization of the Imidazole Ring by Acylacetylene/Aldehyde Pairs

Author(s) -

Trofimov Boris A.,

Andriyankova Ludmila V.,

Nikitina Lina P.,

Belyaeva Kseniya V.,

Mal'kina Anastasiya G.,

Bagryanskaya Irina Yu.,

Afonin Andrei V.,

Ushakov Igor A.

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201501617

Subject(s) - regioselectivity , chemistry , imidazole , aldehyde , surface modification , ring (chemistry) , stereochemistry , medicinal chemistry , organic chemistry , catalysis

The metal‐free regioselective C‐2–H functionalization of 1‐substituted imidazoles has been effected by a cascade reaction with aromatic or heteroaromatic aldehydes and acylacetylenes under mild conditions (55–60 °C, MeCN) to give (imidazol‐2‐yl)methyl‐1,3‐propanediones in 22–77 %, mainly 40–70 % yields.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research