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Palladium‐Catalyzed Aminocarbonylation of Aryl Halides with 2,4,6‐Trichloro‐1,3,5‐triazine/Formamide Mixed Reagent
Author(s) -
Iranpoor Nasser,
Panahi Farhad,
Roozbin Fatemeh,
Erfan Soodabeh,
Rahimi Sajjad
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501607
Subject(s) - chemistry , formamide , cyanuric chloride , aryl , reagent , halide , palladium , catalysis , organic chemistry , 1,3,5 triazine , dimethylformamide , medicinal chemistry , aryl halide , alkyl , solvent
In this work, the mixture of formamide and 2,4,6‐trichloro‐1,3,5‐triazine (cyanuric chloride or TCT) is introduced as a new amidating agent in Pd‐catalyzed aminocarbonylation of aryl halides. In the presence of a catalytic amount of palladium and TCT/formamide reagent, a range of aryl halides (X = Cl, Br, I) were converted into amides efficiently in N , N ‐dimethylformamide at 120 °C.
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