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Multichannel Reaction of α‐Bromoenones with 1,2‐Diamines: Synthesis of 1,4‐Diazabicyclo[4.1.0]hept‐4‐enes by Reaction with N ‐Unsubstituted 1,2‐Diamines
Author(s) -
Muzalevskiy Vasily M.,
Rulev Alexander Yu.,
Kondrashov Evgeniy V.,
Romanov Alexey R.,
Ushakov Igor A.,
Chertkov Vyacheslav A.,
Nenajdenko Valentine G.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501584
Subject(s) - chemistry , reaction mechanism , reaction conditions , medicinal chemistry , diamine , computational chemistry , organic chemistry , catalysis
The reaction of 2‐bromoenones with N ‐unsubstituted 1,2‐diamines was studied. An easy access to 1,4‐diazabicyclo[4.1.0]hept‐4‐enes was developed. The multistep mechanism of the reaction is discussed. Final conclusions on the influence of the structure of the starting 2‐bromoenones and 1,2‐diamines on the direction of the reaction are established.